Incazelo
I-Autocamtide-2-related inhibitory peptide iyi-inhibitor ecaciswe kakhulu futhi enamandla ye-CaMKII enenani le-IC50 lama-40 nM.I-Autocamtide-2-related inhibitory peptide, i-peptide yokwenziwa ye-ATP yenoveli, itholwe iyisivimbeli esinamandla se-CaM kinase II ene-IC 50 yama-40 nM futhi yayisebenza lapho kukhona noma ukungabikho kwe-Ca 2+ / calmodulin.Ngaphansi kwezimo zokuhlola ezisetshenzisiwe, bekunamandla izikhathi ezingama-50 nezingu-500 kune-CaMK-(281-302Ala286) kanye ne-KN-93, ngokulandelana.
Imininingwane
Ukubukeka: Impushana emhlophe ukuya kokumhlophe
Ubumsulwa(HPLC):≥98.0%
Ukungcola Okukodwa:≤2.0%
Okuqukethwe kwe-Acetate(HPLC): 5.0%~12.0%
Okuqukethwe Amanzi (Karl Fischer):≤10.0%
Okuqukethwe kwe-Peptide:≥80.0%
Ukupakisha Nokuthumela: Izinga lokushisa eliphansi, ukupakisha kwe-vacuum, kunembile ku-mg njengoba kudingeka.
Unga-oda Kanjani?
1. Contact us directly by phone or email: +86-13735575465, sales1@gotopbio.com.
2. Oda ku-inthanethi.Sicela ugcwalise ifomu le-oda ku-inthanethi.
3. Nikeza igama le-peptide, Inombolo ye-CAS noma ukulandelana, ukuhlanzeka nokuguqulwa uma kudingeka, ubuningi, njll. sizohlinzeka ngekhotheshini kungakapheli amahora ama-2.
4. Ukugcinwa kwe-oda ngenkontileka yokuthengisa esayiniwe ngokufanelekile kanye ne-NDA(isivumelwano esingadalulwanga) noma isivumelwano esiyimfihlo.
5. Sizoqhubeka nokubuyekeza inqubekelaphambili ye-oda ngesikhathi.
6. Ukulethwa kwe-Peptide nge-DHL, i-Fedex noma abanye, kanye ne-HPLC, MS, COA izohlinzekwa kanye nempahla.
7. Inqubomgomo yembuyiselo izolandelwa uma kukhona ukushayisana kwekhwalithi noma isevisi yethu.
8. Isevisi yangemuva kokuthengisa: Uma amakhasimende ethu enemibuzo mayelana ne-peptide yethu ngesikhathi sokuhlolwa, sicela ukhululeke ukusithinta futhi sizoyiphendula ngokushesha.
Yonke imikhiqizo yenkampani isetshenziselwa inhloso yocwaningo lwesayensi kuphela, yona'kwenqatshelwe ukusetshenziswa ngokuqondile yinoma yimuphi umuntu emzimbeni womuntu.
FAQ:
Isiphi isiphetho esilungele ucwaningo lwami?
Ngokuzenzakalelayo, i-peptide iphetha ngeqembu le-amino lamahhala le-N-terminal kanye neqembu le-carboxyl lamahhala le-C-terminal.Ukulandelana kwe-peptide kuvame ukumela ukulandelana kwephrotheni kamama.Ukuze ube seduze nephrotheni kamama, ukuphela kwe-peptide kuvame ukudinga ukuvalwa, okungukuthi, i-n-terminal acetylation kanye ne-C-terminal amidation.Lokhu kuguqulwa kugwema ukwethulwa kokushaja ngokweqile, futhi kuyenza ikwazi ukuvimbela isenzo se-exonucliase, ukuze i-peptide izinze kakhudlwana.
Imaphi ama-polypeptide alungisiwe anelebula angahlanganiswa ku-peptide yesiShayina?
Inkampani yethu ihlinzeka ngezinhlobonhlobo zokulebula okuguquliwe kwe-peptide, okufana ne-acetylation, ilebula ye-biotin, ukuguqulwa kwe-phosphorylation, ukuguqulwa kwe-fluorescence, nakho kungenziwa ngezifiso ngokuya ngezidingo zakho ezikhethekile.
Ungawancibilikisa kanjani ama-polypeptides?
I-solubility ye-polypeptide incike ikakhulukazi esakhiweni sayo esiyinhloko nesesibili, imvelo yelebula yokuguqulwa, uhlobo lwe-solvent kanye nokugxila kokugcina.Uma i-peptide ingancibiliki emanzini, i-ultrasound ingasiza ukuyihlakaza.Nge-peptide eyisisekelo, kunconywa ukuba ichithe i-acetic acid engu-10%;Kuma-peptide ane-acidic, kunconywa ukuchithwa ngo-10% NH4HCO3.Izinyibilikisi ze-Organic nazo zingangezwa kuma-polypeptides angancibiliki.I-peptide incibilika enanini elincane le-solvent ephilayo (isb, i-DMSO, i-DMF, i-isopropyl alcohol, i-methanol, njll.).Kutuswa kakhulu ukuthi i-peptide incibilikiswe ku-solvent ye-organic kuqala bese yengezwa kancane kancane emanzini noma kwesinye isilondolozi kuze kube yilapho kugxiliswa okufiswayo.
Yiziphi izimo ezingcono kakhulu zokulondoloza?Iqine kangakanani i-peptide?
Ngemuva kwe-lyophilized, i-polypeptide ingenza i-fluff noma i-flocculant powder, engagwema ukuwohloka ngaphambi kwesikhathi kwe-polypeptide.Izimo zokugcina ezinconyiwe: a.-20℃indawo yokugcina noma eyomile b.Zama ukugwema ukuncibilika okuphindaphindiwe c.Zama ukugwema ukugcinwa esimweni sesixazululo (impushana eqandisiwe ingagcinwa emaphaketheni ahlukene ukuze kube lula ukuyisebenzisa) d.Uma kufanele igcinwe kwisisombululo, kunconywa ukuthi ichithe ama-peptide emanzini oyinyumba ngaphansi kwezimo ezibuthakathaka ze-asidi futhi igcinwe ku -20.℃.
Ithuthwa kanjani i-peptide yami?Imiphi imibiko yokuhlola enikeziwe?
Wonke ama-polypeptide omisiwe afriziwe ngokuvamile agcinwa ezitsheni ezikhethekile ezingu-2 ml noma 10ml ezinedatha yokuhlaziya yoqobo kanye nemibiko yokuhlanganisa equkethe ulwazi olubalulekile njengokulandelana, isisindo samangqamuzana, ukuhlanzeka, isisindo, kanye nenombolo ye-polypeptide.
Siyini isisindo esiphelele?Kuyini okuqukethwe kwe-peptide?
Ngemuva kokuthi i-lyophilized peptide ngokuvamile i-fluffy futhi ifana ne-fluff, ingase iqukathe amanani amancane wamanzi, izinyibilikisi ezikhangisiwe nosawoti ngenxa yezimpawu ze-peptide ngokwayo.Lokhu akusho ukuthi ukuhlanzeka kwe-peptide akwanele, kodwa ukuthi okuqukethwe kwangempela kwe-peptide kuncipha ngo-10% kuya ku-30%.Isisindo esiphelele se-peptide yisisindo sangempela se-peptide khipha amanzi nama-ion ane-protonated.Ukuze uqinisekise ukugcwala kwe-peptide, izinto ezingezona i-peptide zidinga ukususwa ku-peptide engahluziwe.
Ingahlanzeka kangakanani i-peptide?
Inkampani yethu ingahlinzeka ngamazinga ahlukene okuhlanzeka ukuze amakhasimende akhethe kuwo, kusukela kokungcolile kuya > kokuhlanzeka okungu-99.9%.Ngokwezidingo zamakhasimende singanikeza ubumsulwa > 99.9% polypeptide ultra-pure.