Isingeniso esifushane se-tidulutide

Indlela yokusebenza ye-tidulutide Gattex (teduglutide)

I-Teduglutide iyi-analogue yomuntu yemvelo ye-glucagon-like peptide-2 (GLP-2), i-peptide efihliwe ngamaseli e-L ku-distal gut.I-GLP-2 yaziwa ngokuthuthukisa ukugeleza kwegazi emathunjini kanye ne-portal futhi ivimbele ukukhishwa kwe-asidi esiswini.Kumadigri e-lu peptide nesamukeli se-peptide 2 amasampula eglucagon, isici sokukhula esifana ne-insulin kumaseli e-endocrine wamathumbu, amaseli e-epithelial we-muscle fiber, i-submucosa kanye nezimo ze-mynteric phakathi kwama-neuron amathumbu.Ukwenziwa kusebenze kwalawa ma-receptor kubangela ukukhululwa kwendawo kwezinhlobonhlobo zemidiya, okuhlanganisa i-insulin-like growth factor (IGF) 1, ukwakheka kwesici sokukhula kweseli i-nitrogen oxide kanye ne-cutin cell growth factor (KGF).

I-Tidulutide, i-analogue efana ne-glucagon-like peptide 2 (GLP-2), yehlisa ukuphuma kwesisu kanye ne-metabolism futhi ilawule ukukhula, ukukhiqizwa kanye nokululama kwamaseli olwelwesi lwamathumbu.I-Peptide yandisa inani eliphelele lala maseli, ingakhuphula ukumuncwa kwamathumbu amancane, inciphise isifo sohudo.I-Short bowel syndrome kubantu abadala ingelashwa ngokomtholampilo.Umuthi usube yimithi yokuqala enconyiwe kweyivelakancane kodwa ebuthaka ngokwedlulele.

Isingeniso esifushane se-tidulutide

I-Chemical formula ye-molecular ye-tidulutide

Imingcele eyisisekelo

Igama: le-c peptide (Teduglutide)

Inombolo: GT-F027

Inombolo ye-CAS: 197922-42-2

Ukulandelana: His-Gly-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-Asn-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn- Trp-Leu-Ile-Gln-Thr-Lys- Ile-Thr-Asp

Ifomula yemolekyuli: C164H252N44O55S

Isisindo se-molecule: 3752.08248