IsiNgisi: Omiganan
Inombolo ye-CAS: 204248-78-2
Ifomula yemolekyuli: C₉₀H₁₂₇N₂₇O₁₂
Isisindo se-molecule: 1779.15
Ukulandelana: ILRWPWWPWRRK-NH2
Ukubukeka: impushana emhlophe noma emhlophe
Indlela u-Omiganan enza ngayo:
I-peptide encane kakhulu ngakho-ke kunzima ukuyibona kanye nokulebula i-proteolysis;Incishiswa ku-C terminus ukuqhubeka nokumelana ne-proteolysis futhi isuse ukushaja okungekuhle kweqembu le-carboxyl.I-amphiphilic futhi ingasebenzisana ngokuqinile nolwelwesi lwamaseli.Kulindeleke ukuthi ulwelwesi lwamaseli lube ngenye yezinto abazihlosile kakhulu.Kuyi-polycation ethanda ukusebenzisana kwawo nolwelwesi lwebhaktheriya olushaje kabi kanye ne-zomeric yangaphandle ye-lipopolysaccharide (LPS) enolwelwesi oluncelisayo esikhundleni se-peptidoglycan.Kubhaktheriya, amandla olwelwesi nawo abi kakhulu kunamaseli ezincelisayo, angase athuthukise ukubopha nokudluliselwa kwama-antibiotic.Isici sokugcina isici somtholampilo sokuthi i-cytidine evimbela ukuvuvukala nayo inomsebenzi kuma-erythrocyte, kuyilapho i-Omiganan ibonakala ine-hemolytic encane.Njengoba kushiwo ngenhla, izinsalela ezikhokhiswayo ze-omiga-nan zitholakala eduze kwe-terminal ngayinye, kude nesifunda esimaphakathi se-hydrophobic ye-peptide, futhi inani eliphelele lokukhokhiswa kwe-peptide likhuphuka lisuka ku-4+ liye ku-5+, elingachazwa ngokunciphisa i-hemolysis. , njengoba lezi zinguquko zingahambisani nezinto ezifana ne-peptide ezihlotshaniswa nolwelwesi oluncelisayo lwe-zwitt-rionic.Lokhu kufakazelwa imiphumela ye-Staubitz nezinye, lapho ucezu olumaphakathi lwe-cetin evimbela ukuvuvukala ku-omiganan luhlotshaniswa nomsebenzi, kuyilapho ucezu lwetheminali lubonakala lulungisa ukucaciswa kwethagethi.
I-Omiganan isetshenziselwa:
I-Omiganan iyinoveli ye-synthetic cationic antimicrobial peptide okwamanje esathuthukiswa ukuvimbela izifo ezihlobene ne-catheter kanye nokwelapha induna ne-rosacea.Kulolu cwaningo, sihlole ukusebenza kahle kokusetshenziswa kwe-topical yejeli ye-omiganan kumamodeli amabili okufakelwa kwesikhumba (esikhumbeni se-vivo porcine kanye nesikhumba se-vivo guinea pig).I-omiganan0 ihlolwe kumodeli ye-ex vivo porcine isikhumba colonization 1 kuya ku-2% we-ejenti yejeli ibonise umphumela oqinile oncike kumthamo ngokumelene nama-bacterium e-Gram-positive kanye ne-Gram-negative kanye ne-yeast, nemiphumela ephezulu ebonwa phakathi kuka-1 no-2%.Kwakungekho mehluko obalulekile emsebenzini phakathi kwe-Staphylococcus aureus engazweli methicillin futhi ethinteka kalula, futhi umsebenzi wezidakamizwa awuzange uthintwe ubukhulu bento egonyiwe.Ijeli ye-Omiganan1% inomsebenzi osheshayo we-antimicrobial, ngokuncishiswa okungu-2.7log(10) kumayunithi enza ikoloni ye-Staphylococcus epidermolis/isayithi ngehora elingu-1 kanye nokwehliswa okungu-5.2log(10) ku-flagella/isayithi emahoreni angama-24 ngemuva kokufakwa.Umsebenzi onamandla wokulwa namagciwane kanye ne-antifungal wejeli ye-Omiganan1% waqinisekiswa ezinye izifundo kumodeli yekoloni yesikhumba sehlengethwa.Kafushane, ama-gel e-Omiganem aboniswe ukuthi anemiphumela esheshayo ye-bactericidal kanye ne-bactericidal enomphumela ocacile oncike kumthamo ku-spectrum ebanzi yezinto ezithathelwanayo.Le miphumela iqhubeka ikhombisa amandla omuthi njenge-ejenti ye-topical antimicrobial.
Isikhathi sokuthumela: Oct-08-2023