Mayelana NATHI:
I-peptide iwuchungechunge lwama-amino acid axhunywe amabhondi e-peptide.Ama-peptide ahileleke kakhulu ekulawuleni amaprotheni, i-angiogenesis, ukwanda kwamaseli, i-melanogenesis, ukufuduka kwamangqamuzana, nokuvuvukala.Ama-peptide e-Bioactive asetshenziswe kabanzi embonini yezimonyo emashumini eminyaka amuva nje.Ama-peptide adinga isisindo esiphansi samangqamuzana (> 500 Da), ukuze kuncishiswe ukusakazeka kwe-peptide phakathi kwezingqimba ze-epidermal, ukuzinza okuphezulu nokuncibilika.Phakathi neminyaka edlule, umphakathi wesayensi uye wasungula ucezu lwe-peptide lokwenziwa oluncane futhi oluzinzile olucupha ukukhiqizwa kwe-collagen futhi lunciphise imibimbi yobuso kanye nombala.I-Trifluoroacetyl tripeptide-2 (uchungechunge: TFA-Val-Try-Val-OH) i-tripeptide synthesis, eklanywe njenge-matrix metalloproteinase kanye ne-elastase inhibitor.Ucwaningo lwe-in vitro mayelana nokuvikelwa kwe-ECM nge-trifluoro-acetyl tripeptide 2(TT2), ukuhlanganiswa kwe-proteoglycan ekusebenzelaneni kwe-cell-matrix, kanye nomthelela ekuhlanganiseni kwe-progerin kuma-fibroblasts avamile abantu asebekhulile kusanda kukhonjwa njenge-co-inducer yamaselula. ukuzwela.Imiphumela iphakamisa ukuthi i-trifluoroacetyl tripeptide 2 inohlu olubanzi lwezindawo zokulwa nokuguga.Lokhu kunciphisa i-progerin synthesis, kwandisa ukukhiqizwa kwe-proteoglycan, futhi kunciphise i-collagen, ngaleyo ndlela kunciphise imibimbi futhi kuthuthukise ukuqina kwezicubu.Ngaphezu kwalokho, imiphumela yayo yokulwa nokushwabana, ukulengiswa kokugeleza kwegazi kanye nemiphumela yokuqinisa isikhumba yahlolwa ezifundweni zobuso ezihlukanisayo ezimbili ze-in vitro.I-Trifluoroacetyl tripeptide 2 ikhonjiswe ukuthi inemiphumela eqhubekayo emibimbi, ukuqina, ukunwebeka, nokuwohloka.
Ingabe i-trifluoroacetyl tripeptide-2 ibambezela ukuguga?
Ucwaningo luye lwabonisa ukuthi i-cell senescence ihlobene eduze ne-Progerin.Ngokuguga, i-presenilin iqoqana kakhulu emzimbeni, okuholela ekulimaleni kwe-nuclear kanye nokulimala kwe-DNA, okuholela ezinhlobonhlobo zokuguga kwesikhumba.I-Trifluoroacetyl tripeptide-2 iyi-tripeptide esebenzayo ye-Elafin, ephuma ku-elastase inhibitor.Yehlisa i-Progerin synthesis futhi ithuthukisa ukuxega kwesikhumba, ukuwohloka kanye nemibimbi.
Indlela
1. Vimbela ukuhlanganiswa kwe-Progerin ukuze kubambezeleke ukuvela kweselula.
2. Khuthaza ukukhiqizwa kwe-syndecan futhi andise ukuphila kwamaseli.
3. Vimbela umsebenzi we-matrix metalloproteinase MMP1, MMP3 kanye ne-MMP9, wehlise ukuwohloka kwamaprotheni e-matrix angaphandle kwamaseli futhi ugcine ubuqotho bawo.
4. Vimbela umsebenzi we-elastase, wehlise ukuwohloka kwe-elastin, futhi wenze isikhumba siqine futhi sinwebeke.
Isicelo
Ilungele zonke izinhlobo zokulwa nokushwabana nokuguga, ukulungisa ukuqinisa, ukuqeda izithombe, ukunakekelwa komzimba ngemuva kokubeletha kanye nelanga, njll. Yengezwe esigabeni sokugcina sokukhiqizwa kwezimonyo.
Isikhathi sokuthumela: May-22-2023