Imboni yonobuhle ibilokhu yenza konke okusemandleni ukwanelisa isifiso sabesifazane sokubukeka bebadala.Eminyakeni yamuva nje, ama-peptide ashisayo asebenzayo asetshenziswe kabanzi embonini yezimonyo.Njengamanje, cishe izinhlobo ezingama-50 zezinto zokusetshenziswa seziqaliswe abakhiqizi bezimonyo abadumile phesheya.Ngenxa yobunkimbinkimbi bezimbangela zokuguga, izinhlobo ezahlukahlukene zama-peptide obuhle zidlala indima ehlukile ezindleleni ezahlukahlukene zokufeza inhloso yokulwa nokushwabana.Namuhla, ake sibheke ama-peptide ahlukahlukene nezinombolo ohlwini lwesithako.
Ukuhlukaniswa kwendabuko kuhlukanise ama-peptide obuhle ngendlela yokwenza ama-peptide esiginali, i-Neurotransmitter inhibiting peptides, kanye nama-peptide Aphethwe.
Eyodwa.Ama-peptide esignali
Ama-peptide amasignali akhuthaza ukuhlanganiswa kweprotheni ye-matrix, ikakhulukazi i-collagen, futhi ingase ikhulise ukukhiqizwa kwe-elastin, i-hyaluronic acid, i-glycosaminoglycans, ne-fibronectin.Lawa ma-peptide akhuthaza ukwakheka kwe-collagen ngokwandisa ukusebenza kwamaseli e-stromal, okwenza isikhumba sibukeke sinwebeka futhi sisisha.Ngokufanayo nezithako zokulwa nemibimbi yendabuko, njengovithamini C, okuphuma ku-vitamin A.Ucwaningo olwenziwe yi-P&G lubonise ukuthi i-palmitoyl pentapeptide-3 ikhuthaza ukukhiqizwa kwe-collagen namanye amaprotheni e-matrix angaphandle kwamaseli, okuhlanganisa i-elastin ne-fibronectin.I-Palmitoyl oligopeptides (palmitoyl tripeptide-1) yenza into efanayo kakhulu, yingakho i-palmitoyl oligopeptides isetshenziswa kakhulu.I-Palmitoyl pentapeptide-3, palmitoyl tripeptide-1, palmitoyl hexapeptide, palmitoyl tripeptide-5, hexapeptide-9 kanye ne-nutmeg pentapeptide-11, ezivame ukuthengiswa emakethe, zingama-peptide esignali.
Okubili.I-Neurotransmitter peptides
Le peptide iyindlela efana ne-botoxin.Ivimbela i-SNARE receptor synthesis, ivimbela ukukhululwa ngokweqile kwe-acetycholine yesikhumba, ivimbele ulwazi lokufinyela kwemisipha yokudluliselwa kwenzwa, futhi iphumuza imisipha yobuso ukuze ithobe imigqa emihle.Lawa ma-peptide asetshenziswa kakhulu njengama-peptide esignali futhi afaneleka ikakhulukazi ukusetshenziswa ezindaweni lapho imisipha yokukhuluma igxilile (emakhoneni wamehlo, ubuso, nebunzi).Imikhiqizo emele i-peptide yile: i-acetyl hexapeptide-3, i-acetyl octapeptide-1, i-pentapeptide-3, i-dipeptide ophiotoxin ne-pentapeptide-3, phakathi kwayo esetshenziswa kakhulu i-acetyl hexapeptide-3.
Ezintathu.Ama-peptides aphethwe
Ama-tripeptides (Gly-L-His-L-Ls(GHK)) ku-plasma yomuntu anobudlelwane obuqinile nama-ion ethusi, angenza ngokuzenzakalelayo i-peptide yethusi eyinkimbinkimbi (GHK-Cu).I-Copper ekhishwe iyisici esibalulekile sokuphulukiswa kwesilonda kanye nezinqubo eziningi zokusabela ze-enzymatic.Ucwaningo luye lwabonisa ukuthi i-GHK-Cu ingakhuthaza ukukhula, ukuhlukaniswa kanye nokuhlukaniswa kwamangqamuzana ezinzwa kanye namaseli ahlobene nokuzivikela komzimba, futhi ingakhuthaza ngokuphumelelayo ukuphulukiswa kwesilonda nokukhula kwamagciwane.Umkhiqizo omelwe i-peptide yethusi yi-peptide yethusi.
Ezine.ezinye izinhlobo ze-peptide
Umsebenzi ojwayelekile wama-peptide wendabuko ulwa nokushwabana nokuguga ngaphandle kwe-peptide yethusi (i-peptide yethusi inezakhiwo eziningi ngesikhathi esisodwa).Eminyakeni yamuva nje, izinhlobonhlobo zama-peptide bezilokhu zanda, ezinye zazo ezifeza inhloso yokunqanda imibimbi kanye nokulwa nokuguga kusuka kumshini omusha nombono (i-anti-free radical oxidation, i-anti-carbonylation, anti-inflammatory, anti - i-edema futhi ikhuthaza ukulungiswa kwesikhumba).
1. I-Anti-sagging isikhumba, khuthaza ukuqina kwesikhumba
I-Palmitoyl dipeptide-5, i-hexapeptide-8, noma i-hexapeptide-10 iqinisa isikhumba ngokuvuselela i-LamininV uhlobo lwe-IV kanye ne-VII collagen, kuyilapho i-palmitoyl tetrapeptide-7 yehlisa ukukhiqizwa kwe-interleukin-6 futhi yehlisa ukuvuvukala.Lolu hlobo lwe-peptide olusebenzayo luyintuthuko esebenzayo, amamodeli amasha akhula njalo, asetshenziswa kakhulu yi-palm tetrapeptide-7.
2. I-Glycosylation
Lawa ma-peptide angavikela i-collagen ekubhujisweni nasekuxhumaneni ngezinhlobo ze-carbonyl esebenzayo (RCS), kuyilapho amanye ama-anti-carbonyl peptide engakwazi ukuqeda ama-radicals mahhala.Ukunakekelwa kwesikhumba kwendabuko kufaka ukubaluleka okukhulu kuma-radicals alwa namahhala, abonakala elwa ne-carbonylation.I-Carnosine, i-tripeptide-1 kanye ne-dipeptide-4 ama-peptide anemisebenzi enjalo
3. Thuthukisa i-edema yamehlo, uthuthukise i-microcirculation futhi uqinise ukujikeleza kwegazi
I-Acetyltetrapeptide-5 ne-dipeptide-2 ama-ACE inhibitors anamandla athuthukisa ukujikeleza kwegazi ngokuvimbela ukuguqulwa kwe-angiotensin I ibe i-angiotensin II.
4. Ukukhuthaza ukulungiswa kwesikhumba
I-Palmitoyl hexapeptidde-6, ithempulethi ye-peptide yofuzo, ingashukumisa ngempumelelo ukwanda kwe-fibroblast nokuxhumanisa, ukuhlanganiswa kwe-collagen kanye nokufuduka kwamaseli.
Ama-peptide angenhla okulwa nokuguga afake iningi lawo.Ngaphezu kwama-peptide aphikisana nokuguga okukhulunywe ngenhla, amanye ama-peptide amaningi wezimonyo athuthukisiwe embonini, njengokumhlophe, ukuthuthukiswa kwebele, ukuncipha kwesisindo nokunye.
Isikhathi sokuthumela: Mar-22-2023