Lawa ma-peptide e-antimicrobial ekuqaleni asuselwa ezinhlelweni zokuzivikela zezinambuzane, izilwane ezincelisayo, izilwane ezihlala emanzini, njll., futhi ahlanganisa ikakhulukazi izigaba ezine:
1. I-cecropin ekuqaleni yayikhona ku-immune lymph lymph ye-Cecropiamoth, etholakala kakhulu kwezinye izinambuzane, futhi ama-peptide abulala amagciwane afanayo nawo atholakala emathunjini engulube.Ngokuvamile zibonakala ngesifunda esine-alkaline ye-N-terminal elandelwa ucezu olude lwe-hydrophobic.
2. I-Xenopus antimicrobial peptides (magainin) itholakala emisipha nasesiswini samaxoxo.Ukwakheka kwe-xenopus antimicrobial peptides nakho kwatholakala ukuthi kune-helical, ikakhulukazi ezindaweni ezingenamanzi.Ukucushwa kwe-xenopus antipeptides ezingqimbeni ze-lipid kwacwaningwa yi-N-lebele ye-NMR yesigaba esiqinile.Ngokusekelwe ekushintsheni kwamakhemikhali kwe-acylamine resonance, ama-helice e-xenopus antipeptides ayeyizindawo ze-bilayer ezihambisanayo, futhi ayekwazi ukuhlangana ukuze akhe ikheji elingu-13mm elinesakhiwo se-helical sezikhathi ezithile esingu-30mm.
3. Ama-peptide e-defensin Defense asuselwa ku-polykaryotic neutrophil rabbit polymacrophages egcwele i-nuclear lobule namaseli amathumbu ezilwane.Iqembu lama-peptide e-antimicrobial afana nama-peptide okuzivikela ezincelisayo akhishwe ezinambuzaneni, ezibizwa ngokuthi "ama-peptide okuvikela izinambuzane".Ngokungafani nama-peptide okuzivikela ezincelisayo, ama-peptide okuvikela izinambuzane asebenza kuphela ngokumelene nama-bacterium e-Gram-positive.Ngisho nama-peptide okuvikela izinambuzane aqukethe izinsalela zeCys eziyisithupha, kodwa indlela yokuhlanganisa i-disulfide komunye nomunye ihlukile.Imodi yokubopha ibhuloho le-intramolecular disulfide ye-antibacterial peptides ekhishwe ku-Drosophila melanogast yayifana naleyo yama-peptide okuvikela izitshalo.Ngaphansi kwezimo zekristalu, ama-peptide okuzivikela ethulwa njengama-dimers.
4.I-Tachyplesin isuselwa ku-horseshoe crabs, ebizwa ngokuthi i-horseshoecrab.Ucwaningo lokucushwa lukhombisa ukuthi yamukela ukucushwa kokugoqa kwe-B okungahambisani ne-parallel (izikhundla ezi-3-8, izindawo eziyi-11-16), laphoβI-angle ixhunywe komunye nomunye (izikhundla ezingu-8-11), futhi amabhondi amabili e-disulfide akhiqizwa phakathi kwezikhundla ezingu-7 nezingu-12, naphakathi kwezikhundla ezingu-3 nezingu-16.Kulesi sakhiwo, i-hydrophobic amino acid itholakala ohlangothini olulodwa lwendiza, futhi izinsalela eziyisithupha ze-cationic zivela emsila we-molecule, ngakho-ke isakhiwo siphinde sibe yi-biophilic.
Kulandela ukuthi cishe wonke ama-peptide e-antimicrobial ane-cationic ngokwemvelo, nakuba ehluka ngobude nokuphakama;Ekugcineni okuphezulu, kungakhathaliseki ukuthi ku-alpha-helical nomaβ-ukugoqa, isakhiwo se-bitropic isici esivamile.
Isikhathi sokuthumela: Apr-20-2023