Indlela yokwenza
Ama-Enzymes angamaprotheni abangela ukusabela kwamakhemikhali.I-enzyme isebenzisana ne-substrate ukuze iguqule ibe umkhiqizo wokugcina.Ama-inhibitors abophana ukuze avimbele i-substrate ukuthi ingangeni endaweni esebenzayo ye-enzyme kanye/noma ivimbele i-enzyme ekubangeleni ukusabela.Kunezinhlobo eziningi zama-inhibitors ezibandakanya: ezingaqondile, ezingahlehliseki, ezihlehliswayo - ezinokuncintisana nezingaqhudelani.Ama-reversible inhibitors abophezela kuma-enzyme ngokusebenzisana okungahlangene (isb, ukusebenzisana kwe-hydrophobic, i-hydrogen ne-ionic bond).Izinyathelo zokulawula ezingaqondile zibandakanya ekugcineni ukukhipha ingxenye yephrotheni ye-enzyme futhi ngaleyo ndlela kugwenywe konke ukusabela komzimba noma kwamakhemikhali.Ama-inhibitors athile asebenza ku-enzyme eyodwa.Ubuthi obuningi busebenza ngokulandela ama-enzyme athile okulawula.Ama-competitive inhibitors ayiwo wonke ama-compounds afana kakhulu nesakhiwo samakhemikhali kanye nejometri yamangqamuzana ye-reaction substrate.I-inhibitor ingasebenzisana ne-enzyme endaweni esebenzayo, kodwa akukho ukusabela okwenzekayo.Ama-Noncopetitive inhibitors yizinto ezisebenzisana nama-enzyme kodwa ngokuvamile azihlanganisi endaweni esebenzayo.Inhloso inetha ye-inhibitor engaqhudelani iwukushintsha ukuma kwe-enzyme, ngaleyo ndlela kuthinte indawo esebenzayo, ukuze i-substrate ingasakwazi ukusebenzisana ne-enzyme ukuze isabele.Ama-non-competitive inhibitors ngokuvamile ayahlehliswa.Ama-Irreversible inhibitors akha izibopho eziqinile ezihlangene nama-enzyme.Amanye alawa ma-inhibitors angasebenza endaweni noma eduze kwesayithi elisebenzayo.
sebenzisa
Ama-Enzymes asetshenziswa kakhulu kwezohwebo emikhakheni yezimboni, njengokuwasha izitsha, izimboni zokudla nezokukhiqiza utshwala.Ama-protease asetshenziswa kuma-“microbial” wokugeza izimpushana ukusheshisa ukuwohloka kwamaprotheni okungcola njengegazi namaqanda.Ukusetshenziswa kwezentengiselwano kwama-enzyme kuhilela ukuthi ayancibilika emanzini, okwenza kube nzima ukuwasebenzisa kabusha, nokuthi eminye imikhiqizo yokugcina ivimbela umsebenzi wama-enzyme (ukulawula impendulo).
Amangqamuzana ezidakamizwa, amangqamuzana amaningi ezidakamizwa ngokuyisisekelo angama-enzyme inhibitors, futhi ama-enzyme inhibitors ezidakamizwa ngokuvamile abonakala ngobunjalo bawo kanye nomthelela wawo.Ukucaciswa okuphezulu nomthelela kubonise ukuthi izidakamizwa zinokusabela okungalungile okuphansi kanye nobuthi obuphansi uma kuqhathaniswa.Ama-Enzyme inhibitors atholakala emvelweni futhi ahlelwa futhi akhiqizwa njengengxenye encane ye-pharmacology kanye ne-biochemistry 6.
Ubuthi bemvelo ngokuvamile bungama-enzyme inhibitors aguquke ukuze avikele izihlahla noma izilwane ezihlukahlukene ezilwaneni ezidla ezinye.Lobu buthi bemvelo buhlanganisa eziningi zezinhlanganisela ezinobuthi kakhulu ezake zatholwa.
Isikhathi sokuthumela: Apr-25-2023