Indlela ye-tripeptide yobuthi benyoka

I-tripeptide yesihlungu senyoka

Izinga lokuhlaziya, i-HPLC≥98%

Igama lesiNgisi: (2S) -beta-alanyl-l-prolyl-2, 4-Diamino-n -(phenylmethyl)butanamide acetate

Iziteketiso: (2S) -beta-alanyl-l-prolyl 2, 4-diamino-n -(phenylmethyl) butyricoacetate;(2S) -beta-alanyl-l-prolyl-2, 4-Diamino-N -(phenylmethyl)butanamide acetate;I-SYN-AKE;inyoka-tripeptide;H – beta – Ala – Pro – Dab – NHBzl.2 akh;Inyoka tr

Inombolo ye-CAS: 823202-99-9

Ifomula yemolekyuli: C19H29N5O3.2(C2H4O2)

Isisindo se-molecule: 495.58

Isingeniso:

Ukulandelana: H-β-Ala-Pro-Dab-NH-Bzl

Ukubukeka: Impushana emhlophe

Isingeniso esifushane:

I-peptide yesihlungu senyoka empeleni iyi-peptide encane elingisa umsebenzi onobuthi wobuthi benyoka.Akuwona ubuthi benyoka, kodwa i-polypeptide yesakhiwo efana nobuthi benyoka.Ama-peptide anobuthi benyoka abesebenza ngokuphindwe kahlanu ekwehliseni imigqa eguquguqukayo kuneBotox, futhi ukuhlolwa kwe-vivo kwabonisa ukuthi ngemuva kwezinsuku ezingama-28 zokusetshenziswa abe nomthelela onciphise imibimbi ngo-52%

Ukusebenza kahle:

1. Ukushwabana nokunqanda ukuguga

2. Ukukhulula umphumela wesikhumba

3. Imikhiqizo yokunakekelwa komuntu siqu yobuso, intamo nezandla

4. Khipha ukuthungwa kwesikhumba, wenze isikhumba sibe mhlophe, sithambile futhi sithambile, sithuthukise ibala lonke

5. Ingangena esikhumbeni esijulile sobuso, igcine isikhumba, futhi isuse iminonjana esele ngeminyaka

6. Dlala umphumela wokuthambisa nokuthambisa, ukuze isikhumba sibe thambile futhi sibushelelezi, sisihle njengakuqala.

7. Ukukhipha amanzi, ukulwa nokuguga, ukukhombisa ubuso obuyiqanda obufana no-V obumanzisa amanzi, bunciphisa ubusha besikhumba sobuso

8. Vikela isikhumba ekukhiqizeni i-melanin

Umthelela:

I-dipeptide diaminobutylbenzylamide diacetate/i-tripeptide efana ne-venom-like ingasetshenziswa njengomkhiqizo ukuze kuthuthukiswe ngempumelelo kanye nokuqeda ubungqabavu ngokuphumuza imisipha yobuso.I-tripeptide yomsebenzi yenza ngendlela efanayo ne-Waglerin1, i-neuromuscle-blocking compound ku-TempleViper venom.Ama-tripeptide afana nobuthi benyoka asetshenziswa kulwelwesi lwe-postsynaptic futhi angabaphikisi abahlehlayo be-muscular nicotinic acetylcholine receptor (nmAChR).I-tripeptide yesihlungu senyoka ebopha i-nmAChRεsubunit ukuvimbela inhlanganisela acetylcholine kanye umphelelisi receptor, okuholela receptor umphelelisi ivaliwe, ezimweni ezivaliwe ion sodium ayikwazi ukusetshenziswa, ayikwazi depolarization, nerve excitation transmission block, imisipha ukuphumula.