I-Palmitoyl pentapeptide-4 ivamise ukusetshenziswa njengejeli yesisekelo semikhiqizo yokunakekelwa kwesikhumba elwa nemibimbi.
I-Palmitoyl pentapeptide-4 (pre-2006 palmitoyl pentapeptide-3) ivamise ukusetshenziswa njengejeli eyisisekelo yemikhiqizo yokunakekelwa kwesikhumba elwa nokushwabana.Kungumkhiqizi wezithako ezisebenzayo zokunakekelwa kwesikhumba ngo-2000 njengemboni yabo yokunakekela njengesithako esisebenzayo, i-palmitoyl pentapeptide-4 iwuchungechunge lwe-peptide yokusetshenziswa kokuqala kanye ne-polypeptide esetshenziswa kakhulu, izinhlobo ezidumile zasekhaya nezangaphandle zisetshenziswa kakhulu njenge isithako esiyisihluthulelo esisebenzayo ekunakekelweni kwesikhumba okunqanda ukushwabana, emikhiqizweni eminingi yokunakekelwa kwesikhumba eqinile elwa nemibimbi ivame ukuvela emfanekisweni wayo.Ngokwandisa i-collagen ngokusebenzisa i-dermis, ingahlehlisa inqubo yokuguga ngokwakha kabusha isikhumba kusuka ngaphakathi nangaphandle.Ithinta i-collagen, imicu yokunwebeka kanye ne-hyaluronic acid ikhuphuka, ikhulise umswakama wesikhumba nokugcinwa komswakama, ikhulise ukushuba kwesikhumba futhi inciphise imigqa emihle.
Palmitoyl pentapeptide-4 (Pal-lys-thr-Lys-ser =Pal-KTTKS) iqukethe amino acid emihlanu exhunywe amaketanga 16-carbon aliphatic ukuze kuthuthukiswe permeability we molecule ngokusebenzisa lipid isakhiwo isikhumba.Lena imajarini.I-Palmitoyl pentapeptide-4 iyi-peptide yesithunywa elawula ukusebenza kweseli ngokuxhumana nama-receptors awo athile.Bavule izakhi zofuzo ezihilelekile ekuthuthukisweni kwe-matrix engaphandle kwamaseli nokwanda kwamaseli.I-Palmitoyl pentapeptide-4 inomphumela wokulwa nokushwabana nokuqinisa isikhumba ngokwenza kusebenze ukuhlanganiswa okusha kwama-macromolecules ku-matrix engaphandle kweseli.
Indlela yokwenza
Ucwaningo lwe-in vitro luthole ukwanda okungama-212% kohlobo lwe-collagen synthesis, ukukhuphuka okungu-100% kuya ku-327% kohlobo lwe-IV collagen synthesis, kanye nokwanda okungama-267% kokuhlanganiswa kwe-hyaluronic acid.I-Collagen I itholakala ezinhlobonhlobo zezinhlobo ezingu-19 ze-collagen emzimbeni.Ngakho-ke, ukwandisa ukukhiqizwa okuphelele kwe-collagen I kunomthelela omkhulu ekwakheni kabusha isikhumba.Ucwaningo lwezinyanga eziyisithupha lwe-vivo luthole ukuncishiswa kwesilinganiso ngamaphesenti angu-17 ekujuleni kwemigqa ecolekile, amaphesenti angu-68 endaweni yemigqa ejulile ejulile, amaphesenti angu-51 endaweni yemigqa emihle ephakathi, namaphesenti angu-16 ebugwegweni. isikhumba.
Isikhathi sokuthumela: Apr-28-2023