I-PYY peptides iyi-antifungal futhi igcina impilo ye-microbial yamathumbu

Lapho ithimba lithola lolu hlobo lwama-C. albicans lisebenzisa i-PYY, idatha yabonisa ukuthi i-PYY ikumise ngempumelelo ukukhula kwalawa magciwane, yabulala izinhlobo eziningi zesikhunta zama-C. albicans futhi igcina uhlobo lwe-symbiotic yeast yama-C. albicans.

Iqembu lika-Eugene Chang eNyuvesi yaseChicago lishicilele iphepha kujenali Isayensi enesihloko esithi: Peptide YY: A Paneth cell antimicrobial peptide egcina i-Candida gut commensalism.

I-YY peptide (PYY) Kuyi-hormone yamathumbu evezwa futhi ikhishwe amaseli e-enteroendocrine (ECC) ukulawula isifiso sokudla ngokudala ukusutha.Ucwaningo lwakamuva luthole ukuthi i-PanethCell yamathumbu engaqondile futhi iveza uhlobo lwe-PYY, olungasebenza njenge-antimicrobial peptide (AMP), nayo edlala indima ebalulekile ekugcineni i-microbiota yamathumbu inempilo futhi ivimbele ama-Candida albicans ekubeni i-pathogenic eyingozi. imodi.

Kuncane okwaziwayo mayelana nokulawulwa kwalawa magciwane yi-gut microbiome yethu.Siyazi nje ukuthi amagciwane akhona, kodwa asazi ukuthi yini eyenza abe wusizo empilweni yethu.Ucwaningo lwakamuva lubonise ukuthi ama-peptide e-YY empeleni abalulekile ekugcineni i-symbiosis yamathumbu emathunjini.

Ekuqaleni, iqembu belingakakulungeli ukufunda amagciwane ku-gut microbiome.Lapho uJoseph Pierre, umbhali wokuqala waleli phepha, efunda ngamaseli e-endocrine wamathumbu e-PYY akhiqiza amagundane, uDkt Joseph Pierre waqaphela ukuthi i-PYY iphinde ibe nama-Panethcell, okuyizivikelo ezibalulekile zesimiso sokuzivikela ezifweni ezincelisayo futhi avimbele ukuphindaphindeka kwamagciwane ayingozi. ngokusebenzisa i-metabolizing izinhlanganisela eziningana ze-bacterosuppressive.Lokhu akubonakali kunengqondo ngoba ngaphambilini i-PYY bekucatshangwa ukuthi iyihomoni yesifiso sokudla.Lapho ithimba lithola amagciwane ahlukahlukene, i-PYY yatholwa inembi ekuwabulaleni.

I-PYY peptides iyi-antifungal futhi igcina impilo ye-microbial yamathumbu

Kodwa-ke, lapho befuna ezinye izinhlobo zama-peptide afanayo ngokwesakhiwo, bathola i-peptide efana ne-PYY -Magainin2, i-peptide elwa namagciwane ekhona esikhumbeni se-Xenopus esivikela izifo ezibangelwa amagciwane kanye nesikhunta.Ngakho-ke, ithimba lahlela ukuhlola izakhiwo ze-PYY ezilwa nesikhunta.Eqinisweni, i-PYY ayiyona nje i-ejenti ye-antifungal esebenza kahle kakhulu kodwa futhi iyi-ejenti eqondile ye-antifungal.

I-PYY engaguquki, engashintshiwe inama-amino acid angu-36 (PYY1-36) futhi iyi-peptide enamandla yokulwa nesikhunta lapho amaseli e-Paneth eyigaxa emathunjini.Kodwa lapho amangqamuzana e-endocrine ekhiqiza i-PYY, ikhishwa ama-amino acid amabili (PYY3-36) bese iguqulwa ibe ihomoni yamathumbu ekwazi ukuhamba emgudwini wegazi ukuze yenze umuzwa wokugcwala otshela ubuchopho ukuthi awulambile.

I-Candida albicans (C.albicans), eyaziwa nangokuthi i-Candida albicans, igciwane elivame ukukhula emlonyeni, esikhumbeni nasemathunjini.I-commensal emzimbeni ngesimo semvubelo eyisisekelo, kodwa ngaphansi kwezimo ezilinganiselwe iguqulela kulokho okubizwa ngokuthi i-fungal shape, eyivumela ukuthi ikhule ngamanani amakhulu, okuholela kuma-thrups, izifo zomlomo nomphimbo, izifo zangasese, noma ezinzima kakhulu. izifo zesistimu.

Lapho ithimba lithola lolu hlobo lwama-C. albicans lisebenzisa i-PYY, idatha yabonisa ukuthi i-PYY ikumise ngempumelelo ukukhula kwalawa magciwane, yabulala izinhlobo eziningi zesikhunta zama-C. albicans futhi igcina uhlobo lwe-symbiotic yeast yama-C. albicans.