Ama-agonists afana ne-Glucagon-like peptide 1 receptor (GLP-1R) atholwe ehlisa ukusetshenziswa kotshwala kumagundane nakubantu abakhuluphele ngokweqile abane-alcohol use disorder (AUD).Kodwa-ke, imithamo ephansi ye-semaglutide (semaglutide), inhibitor enamandla ye-GLP-1, ikhonjiswe ukunciphisa ukusetshenziswa kotshwala kumagundane kanye nabantu abakhuluphele ngokweqile abane-AUD.Amathuba okuthi i-agonist enamandla amakhulu nokusondelana kwe-GLP-1R) inciphise izimpendulo ezihlobene notshwala kumagundane, kanye nezindlela eziyisisekelo zemizwa, awaziwa.
I-Somallutide, isidakamizwa esisetshenziswa njengamanje ekwelapheni uhlobo 2 lwesifo sikashukela kanye nokukhuluphala ngokweqile, singase sibe ukwelashwa okusebenzayo kokuncika otshwaleni.ocwaningweni olushicilelwe kumagazini wamazwe omhlaba i-eBioMedicine enesihloko esithi "I-Semaglutide Yehlisa Ukuphuza Utshwala Nokuphuza Okufana Nokuphuza Emagundaneni Abesilisa Nabesifazane," Ososayensi abavela eNyuvesi yaseGothenburg nezinye izikhungo bathole ukuthi i-somallutide inganciphisa ukubuyiswa kotshwala kanye nokuphuza utshwala kumagundane ngo. ngaphezu kwesigamu.
Isidingo se-somallutide, ethengiswa ngaphansi kwamagama emikhiqizo efana ne-Ozempic (semaglutide), sinyukile kusukela umuthi ugunyazwe ukwelapha ukukhuluphala, okusanda kwenza kwaba nzima kakhulu ukuwuthola;Sekuke kwavela nemibiko engachazeki ngabantu abakhuluphele noma abanesifo sikashukela bethi isifiso sabo sokuphuza utshwala sehlile ngemuva kokuthi beqale ukuthatha lesi sidakamizwa.Kulezi zinsuku, abantu abanomlutha wotshwala baphathwa ngenhlanganisela yezindlela zokuxhumana nabantu kanye nezidakamizwa.Njengamanje kunemithi emine egunyaziwe.Njengoba ukuncika ophuzweni oludakayo kuyisifo esinezimbangela eziningi kanye nokusebenza okuhlukahlukene kwalezi zidakamizwa, ukuthuthukiswa kwezindlela zokwelapha eziningi kubaluleke kakhulu.
I-Somallutide umuthi osebenza isikhathi eside iziguli eziwudinga kuphela kanye ngesonto, futhi umuthi wokuqala osebenza kuma-GLP-1 receptor ongathathwa njengethebhulethi.Kulolu cwaningo abacwaningi belapha amagundane athembele otshwaleni nge-somalutide, okunciphise kakhulu uphuzo oludakayo lwamagundane kwaze kwanciphisa nophuzo oluhambisana nokubuyela emuva, inkinga enkulu kubantu abanotshwala ngoba abantu babuyelwa wutshwala ngemuva kwesikhathi eside bengabuthinti futhi baphuze kakhulu utshwala. kunangaphambili kokuzithiba.Amagundane aselashiwe akwazile ukunciphisa ukuphuza kwawo utshwala ngesigamu uma kuqhathaniswa namagundane angalashiwe, kusho abacwaningi.Ukuthola okuthakazelisayo ocwaningweni kwakuwukuthi i-somallutide yehlisa ukuphuza utshwala ngokulinganayo kumagundane abesilisa nabesifazane.
Ucwaningo luphinde lwabika umphumela omuhle ngokumangalisayo, nakuba izifundo zomtholampilo ze-somallutide zisekude ngaphambi kokuba zisetshenziselwe ukwelapha ukuxhomeka kotshwala;Ukuqhubekela phambili, lesi sidakamizwa singaba nenzuzo kakhulu kubantu abakhuluphele ngokweqile nabancika otshwaleni, futhi abacwaningi bathi imiphumela ingase idlulele kubantu, njengoba ezinye izifundo zezidakamizwa ezincike otshwaleni zisebenzisa amamodeli ocwaningo ahlobene zibonisa ukuthi abantu bangase babe nemiphumela efanayo yokwelapha noma imiphumela. njengamagundane.USolwazi Elisabet Jerlhag uthi, yiqiniso, kunomehluko phakathi kocwaningo olwenziwa ezilwaneni nakubantu, futhi abacwaningi kufanele bahlale bewucabangela lo mehluko;Kulokhu, nokho, ucwaningo lwangaphambilini kubantu luveze ukuthi uhlobo oludala lomuthi wesifo sikashukela osebenza ku-GLP-1 lwatholakala lwehlisa ukuphuzwa kotshwala kubantu abakhuluphele ngokweqile abanomlutha wotshwala.
Ucwaningo lwamanje luphinde lwahlola ukuthi kungani i-somallutide yezidakamizwa inciphisa ukuphuzwa kotshwala komuntu ngamunye, iphakamisa ukuthi ukunciphisa imivuzo yobuchopho obubangelwa utshwala kanye nezijeziso kungase kube isici esinomthelela;Ephepheni, abacwaningi bathola ukuthi kuthinta uhlelo lomvuzo kanye nesijeziso sobuchopho begundane.Ngokucacile, kuthinta indawo ye-nucleus accumbens, eyingxenye yesistimu ye-limbic.Abacwaningi bakholelwa ukuthi utshwala buvula umvuzo wobuchopho kanye nohlelo lwesijeziso, okuholela ekukhululweni kwe-dopamine, engabonakala kubantu nasezilwaneni, futhi le nqubo ivinjiwe ngemva kokuba amagundane eselashiwe, okungase kuholele emvuzweni omncane obangelwa utshwala futhi. isijeziso emzimbeni, abacwaningi bakholelwa.
Sengiphetha, imiphumela yalolu cwaningo iphakamisa ukuthi i-somallutide inganciphisa ukuziphatha kokuphuza utshwala, okungahle kulamule ngokuncishiswa komvuzo/isijeziso esibangelwa utshwala kanye nendlela ye-nucleus accumbens."Njengoba i-somallutide iphinde yehlisa isisindo somzimba kubo bobubili ubulili bamagundane aphuza utshwala, izifundo zomtholampilo zesikhathi esizayo zizohlola ukusebenza kwe-somallutide ekwehliseni uphuzo oludakayo kanye nesisindo somzimba ezigulini ezikhuluphele ngokweqile ezinenkinga yokusebenzisa utshwala."
Isikhathi sokuthumela: Nov-07-2023