Iyini i-conotoxin?Ungakwazi yini ukususa imibimbi?

i-conotoxin (i-conopeptide, noma i-CTX), i-cocktail yama-peptide amaningi anobuthi akhiqizwe amashubhu anobuthi nezindlala ze-Marine gastropod invertebrate Conus (Conus).Izingxenye eziyinhloko ngamakhemikhali e-polypeptide asebenzayo acace kakhulu eziteshini ezithile ze-calcium ezihlukene kanye nama-receptors esistimu yezinzwa.Ubuthi bomnenke we-cone ngamunye buqukethe ama-peptide asebenzayo angama-50 kuye kwangama-200.Izinhlobo ezahlukene zeminenke e-conic iqukethe ama-peptide asebenzayo ahlukene, ngisho noma iminenke efanayo e-conic ngenxa yezifunda ezihlukene, izingxenye zayo ezinobuthi zingahluka, empeleni kungase kube nama-peptide asebenzayo angaphezu kwezinkulungwane ezingama-50 kubuthi beminenke eqinile.I-Conotoxin ngokuvamile yakhiwa izinsalela eziyi-10 ~ 40, eziqukethe amaqembu amabili noma amathathu esibopho se-disulfide, itholakala iyinombolo encane ye-nucleic acid ye-biological neurotoxic peptide, futhi iyi-density enkulu ye-disulfide bond peptide encane, ingasetshenziswa kuzo zonke izinhlobo. yeziteshi ze-calcium nezinhlobo zama-receptor nama-subtypes.

Imiphumela ye-conotoxin ekushwabaneni kwesikhumba imi kanje:

I-Conotoxin, iwumndeni we-conotoxin, iwuhlobo lomphumela owengeziwe wokulwa nokuguga ohlangothini, lokhu kungenxa yokuthi inganciphisa indawo yesikhumba imigqa emincane ukujula, ikhulule ukuqina kwesikhumba, ibe lula futhi inwebeke, iphele imigqa emihle, bese ithola wonke umuntu. intandokazi.Ibizwa ngokuthi “inkanyezi elwa nokuguga.”

I-Conotoxin ingavimbela ukukhiqizwa kwemigqa emihle yobuso, ithuthukise ukukhululeka kwesikhumba, ithuthukise ukunwebeka kwesikhumba, ithuthukise ikhwalithi yesikhumba kanye nokujula komugqa ocolekile.Kuyasiza ekunciphiseni ukuvuvukala kwesikhumba, okuvumela isikhumba ukuba silungise ukunwebeka kwaso futhi sithuthukise izinga lesikhumba.

I-Conotoxin isiphenduke enye yezinketho ezisetshenziswa kakhulu zokulwa nokuguga ngenxa yokusebenza kwayo okuhle kakhulu ekulweni nokuguga.Ngamasu akhethekile, i-conotoxin ingafakwa esikhumbeni sobuso ukuze kuthuthukiswe ukunwebeka kwayo.

I-Conotoxin njengohlobo lwe-ejenti elwa nokuguga, inomphumela oqinile wokulwa nokuguga, ngakho-ke ingazuza kakhulu ukuthuthukisa isimo sesikhumba, ukususa imibimbi, ukwenza isikhumba sibukeke sisebusha sisihle kakhulu nokunwebeka.