I-L-carnosine i-molecule encane enesakhiwo se-dipeptide semvelo esimise okwe-L esivame ukutholakala emvelweni futhi sakhiwe izakhiwo ezimise okwemvelo ze-dipeptide ezivame ukutholakala emvelweni.I-dipeptide eyakhiwe yi-β-alanine ne-L-histidine.I-Carnosine inezinhlobonhlobo ze-antioxidant yamangqamuzana, anti-ukuguga kanye nemisebenzi yokunakekelwa kwezempilo ngokomzimba kanye nemiphumela yezokwelapha, njenge-hypertension, isifo senhliziyo, i-cataract ye-senile, ukululama kwezilonda, i-anti-tumor, ukuhlolwa kwemodeli yomzimba, izici zokulwa nokucindezeleka njalonjalo.
Iqhaza lika
I-Carnosine iyi-carnosine etholwe usosayensi waseRussia uGulevich kanye ne-carnitine.E-United Kingdom, Korea, Russia, nakwamanye amaShayina, ucwaningo luye lwabonisa ukuthi i-carnosine inamandla okulwa ne-antioxidant futhi inenzuzo kubantu.I-Carnosine iboniswe ukuthi isusa izinhlobo ze-oksijeni ezisebenzayo (ROS) ezakhiwe yi-oxidation ngokweqile yama-fatty acids ku-membrane yeseli ngesikhathi sokucindezeleka okwenziwe nge-oxidative, kanye ne-aldehydes e-α-β unsaturated.
Ucwaningo oluningi luye lwathola ukuthi i-N-acetylcarnosine inomphumela omuhle ekuvimbeleni nasekwelapheni kwe-cataract.Olunye lwalezi zifundo lubonise ukuthi i-carnosine ithuthukise i-cataracts ebangelwa ukukhanya kwe-crystalline kumagundane okubangelwa ukuchayeka ku-guanidine.Nakuba lezi zimangalo zisekela izinzuzo eziningi zokucatshangelwa kweso ezifana nokwelashwa kwe-carnotin ye-cataract, kuze kube manje, azikasekelwa ngokugcwele umphakathi wezokwelapha ovamile.I-Royal Orthopedics, isibonelo, yayithe i-carnosine ayiphephile futhi ayisebenzi ekwelapheni ulwelwesi lwama-topical.
Ngokombiko wango-2002, i-carnosine ingathuthukisa ubudlelwano bomphakathi futhi yandise ulwazimagama olusetshenziswa izingane ezine-autism, kodwa ukuthuthukiswa okushiwo ocwaningweni kungase futhi kuvele ekuthuthukisweni, i-placebo, noma ezinye izici ezingabhalwanga kulolu cwaningo.
Indlela ye-synthesis
Njengamanje, izindlela zokukhiqiza i-carnosine zineziphambeko ezivamile: ngenxa yomkhawulo wokusabela ohlangothini, lokhu kusabela ohlangothini kwenziwa ngokubamba iqhaza kwe-L-histidine imidazole ring.I-L-histidine izojikeleza okungenani i-0.8% kwinqubo yokusabela, inciphisa isivuno somkhiqizo;Ngesikhathi esifanayo, kunzima ukuhlukanisa i-L-carnosine ngokuhlanzeka okuhle okuhlanzekile optical kusuka ezixubeni eziyingozi (imodi yayo yokujikeleza, imidazole isomers, njll.), ethinta ukuhlanzeka kwezentengiselwano, ngoba lezi zingxube zinezakhiwo ezifanayo ze-physicochemical ku-L-carnosine.Ngenxa yobukhona balezi zingxube, i-L-carnosine ewumphumela inobuthi, kunokulungiswa okumsulwa kwasekuqaleni.
Indlela entsha yokukhiqiza i-L-carnosine imi kanje: i-phthalic anhydride isabela i-β-alanine nge-phthalic anhydride β-phthaloylalanine, i-chlorinated reagent chlorides phthaloyl-β-phthaloylalanine ku-phthaloyl-alanine β-alanyl chloride;I-L-trialkylsilane protective compound iphendula nge-trialkylchlorosilane noma i-hexahydroxysilane, iphendula nge-phthalyl β-alanyl chloride condensation ye-hydrochloride, isuse iqembu elivikelayo ngotshwala obungenayo i-anhydrous, futhi ihlanganise i-hydrochloride kusisombululo se-alkaline ukuze kutholwe i-intermediate hydrochlorazites hydrochlorazine, umkhiqizo we-premediate hydrochlorazite I-L-carnosine ku-alcohol ye-anhydrous.Lo mkhiqizo uyindandatho ye-imidazole ku-L-protected histidine ukuze ugweme imiphumela emibi yendandatho ye-imidazole ku-L-histidine nezinye izinto, futhi uthole i-L-carnosine ehlanzekile enemiphumela emibi ephansi kanye nesivuno esiphezulu esiphezulu nokuqukethwe.
Isikhathi sokuthumela: Oct-24-2023