I-tripeptide yesihlungu senyoka

Umdwebo wesakhiwo se-serpentin-like venom triplet peptide:

I-tripeptide yesihlungu senyoka

Amazinga okuhlaziya,HPLC≥98%

I-tripeptide yesihlungu senyoka

(2S) -beta-alanyl-L-prolyl-2,4-diamino-N-(phenylmethyl)butanamide acetate

Isibizo: (2S) -beta-alanyl-L-prolyl-2, 4-diamino-N -(benzyl) butyamido acetate;(2S) -beta-alanyl-L-prolyl-2,4-diamino-N-(phenylmethyl)butanamide acetate;I-SYN-AKE;inyoka-tripeptide;H – beta – Ala – Pro – Dab – NHBzl.2 akh;Inyoka tr

Inombolo ye-CAS: 823202-99-9

Ifomula yemolekyuli: C19H29N5O3.2(C2H4O2)

Isisindo se-molecule: 495.58

Isingeniso:

Ukulandelana: H-β-Ala-Pro-Dab-NH-Bzl

Ukubukeka: impushana emhlophe

Mayelana NATHI:

Isihlungu esifana ne-peptide iyi-peptide encane elingisa umsebenzi wobuthi benyoka, futhi esikhundleni sobuthi benyoka, iyi-peptide esebenzayo efana nesakhiwo sobuthi benyoka.I-peptide ye-venom ibisebenza ngokuphindwe kahlanu kune-botulinum ekwehliseni imibimbi, futhi yatholakala yehlisa imibimbi ngamaphesenti angama-52 ngemuva kwezinsuku ezingama-28 isetshenziswa kubantu.

Izinzuzo:

1. Anti-umbimbi futhi anti-ukuguga

2. Thuthukisa ikhwalithi yesikhumba

3. Imikhiqizo yokunakekelwa kobuso, intamo nesandla

4. Thuthukisa ukuthungwa kwesikhumba, wenze isikhumba sibe bushelelezi futhi sithambile, sithuthukise ibala

5. Ingangena ongqimbeni olujulile lwesikhumba, igcwalise i-collagen, futhi isuse iminonjana esele ngeminyaka.

6. Dlala indima yokuthambisa kanye ne-hydrating, yenza isikhumba siqine futhi sibushelelezi, sikhanye futhi sibe sihle

7. Qinisa ukulwa nokushwabana, qinisa kabusha ubuso obumise okwe-V, futhi ubuyisele isikhumba sobusha

8. Vimbela ukukhiqizwa kwe-melanin yesikhumba

Indima:

I-dipeptide diamino-butadibenzyl amide diacetate/venom efana ne-tripeptide iwumkhiqizo osebenzayo oshelelayo futhi omelene nokuqina ngokuphumuza imisipha yobuso ngendlela ehambisana ne-Waglerin 1, isakhi esivimba i-neuromuscular of Temple Viper poison.Ama-tripeptides obuhlungu benyoka asebenza kulwelwesi lwe-postsynaptic futhi angabaphikisi abahlehlayo be-muscle nicotinic acetylcholine receptor (nmAChR).I-tripeptide yesihlungu senyoka ibophezela ku-ε subunit ye-nmAChR futhi ivimbe ukubophezela kwe-acetylcholine kumamukeli, okuholela ekuvinjweni kwesamukeli.Esimeni esivinjiwe, ama-ion e-sodium awakwazi ukungenwa futhi asuswe, futhi ukudluliswa kwe-nerve excitation kuvinjiwe, ngaleyo ndlela ukuphumula kwemisipha.