Leli phepha lichaza kafushane i-ticcotide kanye nemiphumela yayo yezemithi

I-Tecosactideiyi-analogue ye-24-peptide corticotropin yokwenziwa.Ukulandelana kwe-amino acid kuyafana nama-amino acid angama-24 we-amino-terminal ye-corticotropin yemvelo (umuntu, inkomo nengulube), futhi inomsebenzi wokuphila ofanayo nowemvelo we-ACTH."Kubonakala ngokungabi bikho kokusabela kwamasosha omzimba, ngokuvamile ngaphandle kwemiphumela emibi kakhulu, futhi kufanelekile ikakhulukazi ezigulini ezingezwani nomzimba noma ezingasebenzi ku-corticotropin yemvelo yengulube."

“Idala i-adrenal hyperplasia, ikhuthaze ukukhiqizwa kwamahomoni e-adrenocortical, ikakhulukazi (i-cortisol) namanye ama-mineralocorticoid njenge-corticosterone, futhi iphinde ikhuthaze ukukhiqizwa kwama-androgens, kodwa ngomphumela obuthakathaka."

Leli phepha lichaza kafushane i-ticcotide kanye nemiphumela yayo yezemithi

Kube nomthelela omncane ekukhiqizweni kwe-aldosterone.Ingxenye yempilo ngamahora ama-3.Ngo-2008, i-FDA yagunyaza i-Tecokotide evela e-Novartis ukuze kuhlonzwe ukuntuleka kwe-adrenal.Njengamanje kufundwa e-RandboudUniversity ukuze kwelashwe i-idiopathic membranous nephropathy.

Yonke indlela ye-liquid phase synthesis iyindlela yokuhlanganisa ye-ticacotide.Le ndlela inezinyathelo eziningi, isikhathi eside sokuhlanganiswa, futhi idinga ama-catalyst abizayo kanye nemishini yokucindezela okuphezulu, enezinkinga zezindleko eziphezulu, ukungcola okuningi, ingozi yokusebenza, kanye nesivuno esincane.Kuye kwabikwa ukuthi ukuhlanganiswa ngamunye ngamunye usebenzisa isu lokuvikela i-Z, lapho i-hydrogenation isetshenziselwa ukususa isisekelo sokuzivikela esinyathelweni ngasinye, inezinyathelo ezinde, ukusebenza kanzima, izindleko eziphezulu kanye nesivuno esincane.I-Serine ijwayele ukugijima ngenxa yokuhlangana komuntu ngamunye ngesikhathi sokuhlanzwa, okunzima ukuyihlanza.

Njengehomoni ye-adrenocorticotropic, i-ticcotide ikhuthaza ukukhiqizwa kwamahomoni e-cortical (ikakhulukazi i-cortisol) asuka ku-adrenal cortex."Ngakho-ke, kwakungekho mphumela ezigulini ezinokukhubazeka okukhulu kwe-adrenocortical.

I-Ticocotide iyi-polypeptide yokwenziwa equkethe ama-amino acid angama-24.Iyafana ngesakhiwo neyokuqala ukuya kuma-amino acid angama-24 we-ACTH.Ukuphathwa kwe-intravenous kukhulisa ngokushesha amazinga e-cortisol yegazi.I-drip eqhubekayo ye-intravenous kufanele isetshenziselwe ukugcina ukugxila kwe-cortisol egazini.Ngomjovo we-intramuscular, i-serum cortisol ifinyelele isiqongo sayo ngehora elingu-1 ngemuva komjovo.Ngemva kwalokho, i-cortisol ephakeme ingagcinwa cishe amahora angu-24.