isingeniso
I-Gorelatide, eyaziwa nangokuthi i-n-acetyl-serine – aspartic acid – proline – proline -(N-Acetyl-Ser-Asp-Ls-Pro), efushanisiwe njenge-Ac-SDKP, iyi-tetrapeptide engapheli, i-nitrogen end acetylation, isatshalaliswa kabanzi izicubu ezihlukahlukene noketshezi lomzimba emzimbeni.Le tetrapeptide ikhishwa yi-prolyl oligopeptidase (POP), ebangelwa kakhulu yi-thymosin eyandulelayo.Ukugxila egazini kuvamise ukuba esikalini se-nanomole.
i-okinetics
Ngokusho kocwaningo lwe-pharmacokinetic lwe-Goreratide, ngemuva kokujova ngomjovo, i-Goreratide iyancipha ngokushesha nge-half-life ye-4 ~ 5min kuphela.I-Goreratide isuswa ku-plasma yomuntu ngezindlela ezimbili:①I-angiotensin-converting enzyme (ACE) -i-hydrolysis eqondiswayo;②Ukuhlunga kwe-Glomerular.I-hydrolysis ye-angiotensin converting enzyme (ACE) iyindlela eyinhloko ye-gorelatide metabolism.
Umsebenzi webhayoloji
I-Goreratide iwuhlobo lwesici sokulawula sokuphila esisebenza ngezindlela eziningi esinemisebenzi ehlukahlukene yebhayoloji.Ngaphambilini kubikwe ukuthi i-Goreratide ingavimbela ukungena kwamangqamuzana okuqala e-hematopoietic stem esigabeni se-S futhi awenze amile esigabeni se-G0, avimbele umsebenzi wamaseli we-hematopoietic stem.Kwabe sekutholakala ukuthi i-Gorelatide ingathuthukisa amandla okutshala kabusha kwe-epidermal ngokukhuthaza ukwakheka kwemithambo yegazi futhi isheshise ukuphulukiswa kwesilonda kumagrafti e-epidermal e-vascularized ewonakele.I-Goreratide ingavimbela ukuhlukaniswa kwamaseli we-bone marrow stem akhuthazwa yi-MGM abe ama-macrophages, ngaleyo ndlela adlale indima ephikisana nokuvuvukala.I-Goreratide isanda kutholwa ukuthi ivimbela ukwanda kwamaseli ahlukahlukene.
sebenzisa
Njengento ephilayo ye-polypeptide, i-Goreratide ingasetshenziswa njengento eluhlaza yesidakamizwa.
Isikhathi sokuthumela: Apr-26-2023